It has been proven that CXCR6 plays a prominent role in CD8 + T-cell enrichment and maintenance in various tissues including NPC, which was previously attributed to its nuclear factor NF-kB activation and CXCR6-mediated cellular interactions such as IL-15 trans-presentation via IL-15Rα (Parsonage et al. 2012; Pilato et al. 2021). Here, CXCR6 is linked to nasopharyngeal carcinoma.