IL-10-producing B cells in the bone marrow have been reported to be reduced in patients with aplastic anemia (AA) compared to healthy individuals, and IL-10-producing CD24hiCD38hi Bregs reduced bone marrow failure.34 This possibility is also supported by evidence that IL-10 related DCs improved hematopoiesis and survival in an AA murine model, with decreased Th17 and increased Treg cells.35,36 Thus, these studies suggest a potential mechanism for IL-10 to alleviate chemotherapy-related toxicity in the hematopoietic and digestive systems. Here, IL10 is linked to idiopathic aplastic anemia.