After adjustment for the predictors age, NIHSS on admission, ASPECTS on admission (8–10vs 0–7), mechanical thrombectomy (yes/no), systemic lysis therapy (yes/no), and pre-stroke mRS (0–2vs 3–6) NfL [OR 2.6 (95% CI: 1.6; 4.6)] and GFAP [OR 2.2 (95% CI: 1.6; 3.1)] displayed an association with poor outcome. The gene discussed is GFAP; the disease is Stroke.