However, how this process relates to tumourigenesis remains unclear.60 IFIT1 has been identified as a potential oncogene involved in F. Nucleatum-induced CRC tumour progression.61 In addition, IFIT1 up-regulation is associated with oral squamous cell carcinoma progression and non-small cell lung cancer.62,63 Our enrichment analyses revealed that defence response to symbiont, defence response, and cytokine-mediated signalling pathways were up-regulated processes in the tumours of mice transplanted with faeces from MI mice. Here, IFIT1 is linked to oral cavity squamous cell carcinoma.