CD8A and neoplasm: While the relationship between HPD and a tumor subtype characterized by IFN‐γ—a cytokine often associated with antitumor responses including the recruitment of CD8+ cells and upregulation of the antigen‐presenting machinery—may seem paradoxical, growing evidence shows that IFN‐γ signaling can also have varying effects depending on the balance of tumor and immune cells in the TME, each of which respond differently to IFN‐γ signaling.48