A recent study by Zou et al49 reported that patients who experienced HPD highly expressed fibroblast growth factor 2 (FGF2) and Wnt‐β‐catenin gene signatures; through preclinical models, the authors demonstrated that IFN‐γ production by CD8+ T cells may alter the PKM2/NAD+/β‐catenin signaling to enhance the tumor's oncogenic potential. Here, PKM is linked to neoplasm.