In addition, higher pT‐stage, higher nuclear grade, the presence of peripelvic fat invasion, macrovascular and microvascular invasion, histological tumor necrosis and cytoplasmic expressions of HIF‐1α and HIF‐2α were significantly associated with a higher risk of disease recurrence or death from RCC in univariable analysis in both cohorts. This evidence concerns the gene EPAS1 and renal cell carcinoma.