Through the concerted effort of C‐REV, which recruits newly‐infiltrated – unexhausted PD1‐low – CD8+ T‐cells, and 2′3′‐cGAMP, which constantly activates CD8+ T‐cells against tumor antigens, the immunosuppressive ‘cold’ TME could be transformed to a ‘hot’ immunogenic TME. Here, CD8A is linked to neoplasm.