PRAME and esophageal squamous cell carcinoma: There are antigens specifically located in certain types of tissues and cells, such as normal testicular germ cells or trophoblasts of the placenta, among others, such as Preferentially expressed Antigen in Melanoma (PRAME), Melanoma Antigen Gene (MAGE) and The CTA New York Esophageal Squamous Cell Carcinoma-1 (NY-ESO-1), also known as cancer-testis antigen 1B (CTAG1B).