With a similar virus infection setup as described for the PVR-/-;PVRL2-/- cells (Figure 2e), we synchronized virus attachment to the HST2ST1 KO and control cells on ice for an hour, treated them with the acid wash at 3h.p.i., then harvested the total viruses produced by these cells at 16h.p.i. This evidence concerns the gene NECTIN2 and viral infectious disease.