This study showed that four polymorphisms associated with inflammation and severe COVID-19, e.g., IL-6 rs1800796, IL-10 rs1800896, TNF-α rs1800629, and IFITM3 rs12252, did not cause predisposition to developing post-COVID symptomatology in a cohort of previously hospitalized COVID-19 survivors infected during the first wave of the pandemic. This evidence concerns the gene IFITM3 and COVID-19.