Isolation of CCoV-HuPn-2018 from hospitalized patients with pneumonia and the introduction of an oligosaccharide at position N739 of the human aminopeptidase N (APN), rendering cells susceptible to CCoV-HuPn-2018 spike-mediated entry, suggest that this virus is a potential HCoV [19,40]. Here, ANPEP is linked to susceptibility to pneumonia measurement.