CD8A and viral infectious disease: In addition, a previous hypothesis has indicated that CD8+ T cells play a critical role in the antiviral response during acute viral infections, while B cells are responsible for the prevention of infection and eventual viral clearance [45], and a prospective cohort study with a small sample size demonstrated that prolonged shedding of SARS-CoV-2 in immunocompromised patients was significantly associated with the level of the neutralizing antibody response [46].