The initial VOC, Alpha, which became the dominant variant in much of Europe and North America in the first months of 2021, was shown to be more resistant to IFITMs than the parental Wuhan-Hu-1 virus, with resistance to the antiviral protein IFITM2 and enhancement of infection by its paralogue IFITM3 [43]. Here, IFITM2 is linked to infection.