Additionally, ZIKV infection significantly reduces the cellular levels of miR-142-5p, which has been demonstrated to inhibit the expression of the IL-6 signal transducer (IL6ST); IL6ST is associated with T cell response and the activation of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway, playing a role in antiviral defense [67]. This evidence concerns the gene IL6ST and Zika virus infectious disease.