EDC3 and Zika virus infectious disease: During ZIKV infections, sfRNAs bind various intracellular RNA-binding proteins, including several antiviral factors linked to RNA decay (such as DEAD-box helicase 6 [DDX6] and enhancer of mRNA decapping 3 [EDC3]) and RNA splicing (such as phosphorylated adaptor for RNA export [PHAX] and splicing factor 3b subunit 1 [SF3B1]), ultimately attenuating the cellular antiviral response [33].