ART4 and viral infectious disease: Recent studies have reported that gB is the most conserved glycoprotein in herpesviruses, and during viral infection of host cells, gB causes viral adsorption to the cell surface by binding to the cellular marker receptor acetyl heparin sulfate; the protein conformation of gB is altered to produce an anchoring-like effect that further drives fusion of the viral envelope with the host envelope [7,8].