Insulin resistance is associated with elevated proinflammatory cytokines and the activation of innate responses, such as toll-like receptors (TLRs), inducible nitric oxide synthase (iNOS), protein kinase R (PKR), c-Jun N-terminal kinase (JNK), and NF-κB, which are connected to insulin receptor and its downstream signaling pathway IRS/PI3k/Akt [82]. The gene discussed is NOS2; the disease is Insulin resistance.