Regarding the host condition, some markers have been associated with increased susceptibility to active TB in HIV-seropositive patients, such as the polymorphism Asp299Gly in the tlr4 gene [23], and mutations at positions 333 and 637 of the tap1 gene have been recognized as risk factors for developing TB coinfection in HIV-positive individuals [24]. The gene discussed is TAP1; the disease is tuberculosis.