In contrast, Waldemar Popik et al. had shown that HIV-1-induced EVs contain cellular cytidine deaminase APOBEC3G, which is one of the primary host defense elements that inhibits reverse transcriptase activity; thus, the transfer of APOBEC3G via EVs may propagate antiviral effects against downstream HIV-1 infection [133]. The gene discussed is APOBEC3G; the disease is HIV-1 infection.