Moreover, these molecules seem to be involved in the comorbidities associated with psoriasis; therefore, a negative correlation was observed between HDL cholesterol levels and FGL1, indicating a possible role of FGL1 in psoriasis forms associated with lipid metabolism disorders [38] or YKL-40 may be involved in endothelial dysfunction [17]. The gene discussed is CHI3L1; the disease is endothelial dysfunction.