NFKB1 and psoriasis: Oxidative stress in psoriasis triggers the initiation of numerous signalling pathways (such as NF-κB and MAPK, STAT 3), leading to the activation of Th1 and Th17 cells and the release of a plethora of pro-inflammatory cytokines that contribute to the hyperproliferation of keratinocytes, immune cell infiltration into the skin and alterations in blood vessel permeability [62].