Although IFN type II, known as IFN-γ, has a similar nomenclature to IFN type I, it is signaled via a different receptor, has effects that are independent of IFN type I and is mainly produced by natural killer cells during infection (2 IFN-γ was originally identified 30 years ago as an antiviral agent and has since been characterized as a homodimeric glycoprotein with pleiotropic immunological functions). Here, IFNG is linked to infection.