PRKN and lung carcinoma: Also, as an active therapeutic structure, oleanolic acid (OA) was selected for its anticarcinogenic potential [92,93], knowing to interfere with different pathways of lung cancer development, such as DNA fragmentation and caspase-3 activation of non-small lung cancer cell lines (A549 and H460) possessing multi-drug resistance proteins [51]; mitophagy via a Parkin independent pathway in A549 cells [94]; or cell cycle arrest of lung cancer cells through miR-122/Cyclin G1/ MEF2D pathway [95].