The sdAb targeting Her2/neu was radiolabeled with I-131 via the tumor residualizing prosthetic group N-succinimidyl 4-guanodinomethyl-3-[131I]I-benzoate ([131I]I-SGMIB), which was introduced into the field by Zalutsky in 2007 [25]. The gene discussed is ERBB2; the disease is neoplasm.