TNF and rheumatoid arthritis: The various types of nanocarriers have been utilized in the delivery of biologics for the treatment of RA, i.e., the polymeric nanoparticles of adalimumab, rituximab, and trastuzumab [112], the lipid nanoparticles of TNF-α siRNA [113], polyamidoamine dendrimers functionalized with anti-TNF-α antibody as well as chondroitin sulphate [114], and nanoparticle-loaded hydrogels to target TNF-α [115].