One hundred and forty-six important signaling pathways were implicated, including neurodegeneration (hsa05022), the Alzheimer’s disease pathway (hsa05010), the NF-kappa B signaling pathway (hsa04064), the HIF-1 signaling pathway (hsa04066), apoptosis (hsa04210), and the EGFR tyrosine kinase inhibitor resistance signaling pathway (hsa01521). The gene discussed is EGFR; the disease is early-onset autosomal dominant Alzheimer disease.