14-3-3θ inhibition can affect the proliferation and metastasis of breast cancer cells via a mechanism related to inactivation of the Rapidly accelerated fibrosarcoma/extracellular regulated protein kinases (RAF/ERK), PI3K/AKT, and Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathways [46,47,48]. The gene discussed is RAF1; the disease is breast cancer.