According to Tam EMYY et al., a decrease in the number of lymphocytes and increased values of CPK, LDH, PCR, and PCT are significant in the group of elderly patients with an unfavorable evolution, in which a higher rate of acute renal failure is also found (76.5% vs. 15.5%) along with coinfections (41.2% vs. 13.1%) [44]. Here, PIK3C2A is linked to coinfection.