MAPT and Alzheimer disease: These effects are exerted via the regulation of several signaling pathways, such as the PI3K/Akt, AMPK-mTOR, and NF-κB pathways, to inhibit or ameliorate key AD features, including Aβ accumulation, neurotrophic factors, tau phosphorylation, neuroinflammation, apoptosis, and mitochondrial dysfunction at different stages of AD [5].