Also, HL036, a molecularly engineered TNF Receptor 1 fragment, improves corneal staining, reduces ocular discomfort, suppresses lacrimal inflammation, decreases corneal inflammation, and improves goblet cell counts by suppressing IFN-γ, IL-21, and IL-6 in a dry eye-induced C57BL/6 mice model [74]. The gene discussed is IL21; the disease is dry eye syndrome.