Other studies have shown that the antagonism of D1-like receptors (both D1 and D5) inhibits Th17 differentiation in experimental autoimmune encephalomyelitis (EAE) [76], and the agonism of these receptors on human PBMCs impairs CD8+ Treg differentiation and activity. The gene discussed is CD8A; the disease is experimental autoimmune encephalomyelitis.