The electrophoresis of the HDL, at 144 h incubation, showed that the treatment of CML into HDL caused remarkable degeneration of the HDL band intensity (lane 2), approximately 15% lower than that of PBS-treated HDL (lane 1), as shown in Figure 5B. Conversely, the co-treatment of rHDL exhibited notable protection against CML-induced proteolytic degeneration of apoA-I in a dose-dependent manner. Here, APOA1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.