In addition, the majority of human malignancies analyzed revealed that “amplification” was the primary form of genetic modification, except for diffuse large B-cell lymphoma, colorectal adenocarcinoma, skin cutaneous melanoma, mesothelioma, and acute myeloid leukemia, in which “mutation” was identified as the predominant RFC4 genetic alteration (Figure 7A). This evidence concerns the gene RFC4 and cutaneous melanoma.