AD [58] is also a representative neurodegenerative disease caused by the loss of neurons due to the aggregation of amyloid β (Aβ), forming extracellular oligomers, protofibrils, and amyloid fibrils, and tau aggregation, forming intracellular neurofibrillary tangles (NFTs). The gene discussed is MAPT; the disease is neurodegenerative disease.