Oxidative stress-induced DNA damage activates the NF-κB, MAPKs, and mTOR pathways, and colchicine has a protective effect against cardiovascular disease due to its ability to block oxidative stress-induced endothelial cellular senescence through inhibition of the NF-κB and MAPKs pathways, inhibit inflammation, and reverse SASP [100]. The gene discussed is NFKB1; the disease is cardiovascular disorder.