To extend these results obtained in the MV4-11 human AML cell line, we performed more rigorous analyses by testing synergy in another human AML common cell line, OCI-AML3, which carries additional AML mutations such as DNA methyltransferase 3 alpha (DNMT3A), Nucleophosmin 1 (NPM1), and neuroblastoma ras viral oncogene homolog (NRAS). This evidence concerns the gene DNMT3A and acute myeloid leukemia.