MP-A08 induces AML cell apoptosis by inhibiting MCL-1 through SPHK1 inhibition, leading to ceramide accumulation, the activation of protein kinase R, the upregulation of activating transcription factor 4 (ATF4), and the activation of phorbol-12-myristate-13-acetate-induced protein 1 (Noxa), ultimately resulting in MCL-1 degradation [16]. This evidence concerns the gene PMAIP1 and acute myeloid leukemia.