Targeting URAT1, a system for the discovery of novel uricosurics was established, including the cell model based on the non-isotopic microscale uric acid detection technique in URAT1-overexpressed HEK293 cells, the sub-HUA mouse model characterized as transient severe hyperuricemia, and the Ch-HUA mouse model characterized as chronic steady hyperuricemia. Here, SLC22A12 is linked to hyperuricemia.