In the unadjusted recessive model, carriers of the TLR8 rs3764880 A/A (OR = 1.90, 95% CI: 1.00–3.59, p = 0.04, G/G-A/G vs. A/A) genotype were associated with a higher risk of developing pulmonary TB. This evidence concerns the gene TLR8 and pulmonary tuberculosis.