As excessive amounts of adipose tissue in the course of obesity are associated with increased secretion of pro-inflammatory cytokines and leptin and decreased secretion of the anti-inflammatory adipokine, adiponectin [125], it has been demonstrated that pro-inflammatory factors may act as a mediator in the relationship between obesity and the development of asthma [122]. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.