Meanwhile, levels of p-ERK and p-JNK elevated in the 2’-HC-treated group whereas the expression of p-p38 remained unaltered (Figure 5B), suggesting that extracellular regulated protein kinases (ERKs)/mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK)/MAPK but not p38/MAPK participated in the regulation of 2’-HC on breast cancer cells. Here, WNK2 is linked to breast cancer.