MAPK8 and neoplasm: Figure 7C shows that the number of TUNEL-positive cells increased in tumor tissues after 2’-HC management, consistent with the results of an elevated expression of c-PARP in the 2’-HC-treated group (Figure 7B). These results suggest that 2’-HC induced apoptosis in xenograft tumors. We also observed an upregulation of LC-3II (Figure 7B) and p-JNK and a downregulation of p-IκB and p-NF-κBp65 following 2’-HC treatment (Figure 7D).