PNPLA3 and type 2 diabetes mellitus: Moreover, a recent longitudinal study (407 T2DM-MASLD patients followed-up for 11 years) showed that combined polymorphisms of the PNPLA3 and TM6SF2 (two or more risk alleles) significantly increased the risk of cirrhosis (OR: 18.48 [6.15–55.58]; p < 0.001) and of cirrhosis complications (OR: 27.20 [5.26–140.62]; p < 0.001) [77].