GDF15 and metabolic dysfunction-associated steatotic liver disease: A high-throughput RNA sequencing approach analyzing 206 samples from a histologically defined NAFLD cohort revealed and validated a gene signature for fibrosis progression, with 25 genes differentially expressed through fibrosis stages F2 to F4, and further analysis at the protein level identified aldo-keto reductase family 1 member B10 (AKR1B10) and growth/differentiation factor 15 (GDF15) concentrations as being strongly correlated with fibrosis stage [75].