The meta-analysis by Singal et al. (24 studies with 9915 patients) reported that the PNPLA3 rs738409 SNP is associated with fibrosis severity (OR: 1.32 [1.20–1.45]), and the risk was similar in patients with NAFLD and with other liver disease etiologies [63]. Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.