The polymorphism of PNPLA3, which codes adiponutrin, a protein involved in lipid remodeling of hepatic triglycerides, mediates NAFLD risk: the single-nucleotide polymorphism (SNP) rs738409 determines a missense variation (I148M) that disrupts the enzymatic activity interfering with lipid catabolism, and has been shown to associate with liver fibrosis and disease progression [61,62,63]. The gene discussed is PNPLA3; the disease is Hepatic fibrosis.