The same impact of the combination of the risk alleles (common genetic variants of PNPLA3, TM6SF2, and HSD17B13) on the severity of NAFLD was also demonstrated by a large cohort study (110,761 individuals from Denmark and 334,691 individuals from the UK Biobank) [78]. Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.