In high-risk asymptomatic patients (based on the European SCORE model) without known CAD, hs-CRP has been found to be an independent predictor of myocardial perfusion defects and has been suggested to be used as a criterion to guide myocardial SPECT imaging [30], which also seems to apply for patients with chronic kidney disease [50,51,52]. This evidence concerns the gene CRP and coronary artery disorder.