IL4 and Alzheimer disease: The cytokine TSLP is a potent stimulator of IL-4 and IL-13: in cutaneous inflammatory conditions such as AD, keratinocytes are the main source of TSLP, the production of which is induced by fibroblast-derived periostin, which in turn is stimulated by IL-4 and IL-13 within a proinflammatory milieu [72].