In another research focusing on the role of prognostic biomarkers both of IPF and SSc-ILD, the authors found a significant association between IL-6 and a decline in gas exchange; no significant association was reported for IL-8, CCL2/MCP-1, IL-10, CXCL10/IP-10, the vascular endothelial growth factor (VEGF), the fibroblast growth factor (FGF)-2, and CX3CL1/fractalkine [62]. This evidence concerns the gene CXCL10 and systemic sclerosis.