The potential causes of cardiovascular disease in COVID-19 infection include: the damage from direct viral invasion of cardiomyocytes, causing cell death, endothelial cell infection, the transcriptional alteration of multiple cell types, complement activation and complement-mediated coagulopathy and microangiopathy, the downregulation of ACE2 receptors and the dysregulation of the renin–angiotensin–aldosterone system, autonomic dysfunction, and elevated levels of pro-inflammatory cytokines that can induce fibrosis and scarring of cardiac tissue [24,25,26]. Here, REN is linked to cardiovascular disorder.