Prostatic adenocarcinoma showed essentially preserved PACAP38 immunopatterns compared to those in normal prostatic glands [64], and no significant alterations in PACAP38-like immunoreactivity detected by RIA were found in cases of urinary bladder tumor samples, prostatic adenocarcinoma samples, or various types of testicular malignancies, like seminoma, embryonal carcinoma, yolk sac tumor, and teratoma [63]. This evidence concerns the gene ADCYAP1 and urinary bladder neoplasm.