HADHA and familial pancreatic carcinoma: Integrated lipidomics and proteomics revealed in 2021 acyl fatty acid alterations in pancreatic cancer stem cell cardiolipin [23], an upregulation of hydroxyacyl-coenzyme A (CoA) dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein HADHA, the α-subunit of mitochondrial long chain fatty acid β-oxidation trifunctional enzyme) in pancreatic cancer stem cells [23], and upregulation of long chain fatty acid elongation enzymes in pancreatic cancer stem cells [23].