AKT1 and cancer: A number of in vitro studies revealed that lanatoside C induced mitochondrial membrane potential loss and apoptosis via its action on protein kinase δ [37], induction of G2/M cell cycle arrest and inhibition of cancer cell growth by attenuating the MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways [38].