The study further demonstrated that when DR5 was suppressed, FADD and caspase 8 might recruit and stabilize TRAF2 to form metastatic and invasion signaling complexes, which in turn leads to the activation of ERK and JNK/AP-1 signaling to mediate the elevation/activation of matrix metalloproteinase-1 (MMP1), ultimately promoting cancer invasion and metastasis [52]. Here, CASP8 is linked to cancer.