KDR and fibrosarcoma: Epidermal growth factor receptor (EGFR), vascular endothelial growth factor receptor-2 (VEGFR-2), B rapidly accelerated fibrosarcoma (BRAF), phosphoinositide 3-kinase (PI3k), and mesenchymal–epithelial transition factor (c-Met) are among the protein kinases that are suppressed by quinazolines (Figure 1).