NFKB1 and amyotrophic lateral sclerosis: The authors showed that Ashwagandha root extract in transgenic mice with ALS (5 mg per mouse, by gavage, every other day for 16 weeks) or withaferin A in FTLD transgenic mice (5 mg/kg, i.p., every other day for 8 weeks) improved motor (ALS) and cognitive (ALS, FTLD) performance while reducing NF-κB activity and inflammation in the brain.