TNF and neuropathic pain: In CCI neuropathic pain, i.p. gallic acid (22) (100 mg/kg) for 1 week increased mechanical withdrawal threshold and thermal withdrawal latency accompanied by inhibition of the upregulated expression of P2X7 and TNF at both mRNA and protein levels and reduced NF-κB and phosphorylated-STAT3 in the dorsal root ganglia.