With the help of the “CytoNCAA” plug-in in Cytoscape v3.7.2, the top 10 targets in the hyperlipidemia and thrombosis network (ESR1, MMP9, HSP90AA1, RELA, IL2, PRKACA, APP, MMP2, HNF4A, and PRKCA) were determined according to their degree values. The gene discussed is ESR1; the disease is hyperlipidemia.